Browsing by Author "Mbotoni, Tatu Seif"

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    Prevalence and factors associated with impaired lung function in children with sickle cell disease-acomparative cross-sectional study in Dodoma city, Tanzania
    (The University of Dodoma, 2022) Mbotoni, Tatu Seif
    Children with Sickle Cell Disease (SCD) are susceptible to several recurrent lung injuries that might lead to progressive impaired lung function. The magnitude and factors associated with this complication in Tanzania which is the fourth highest SCD prevalence globally is unknown. Lung function evaluation among children with SCD is not routinely performed. This study was conducted to determine the prevalence and factors associated with impaired lung functions in children with SCD compared to non-SCD. This was a comparative cross-sectional study conducted from December 2021 to May 2022 enrolling 115 children, 59 with SCD and 56 non SCD aged 6 -18 years. A semi structured questionnaire was used to collect demographic and clinical details of children with SCD and their comparative group. Lung function test was `performed using spirometry ndd Easy OneTM spirometer (Medizintechnich Switzerland). Lung function impairment was defined as any value below the predicted lower limit of normal (FEV1/FVC below 85% of predicted value for obstructive and FVC below 80% for restrictive). Hemoglobin level was measured and hemoglobin electrophoresis for the SCD group. Frequency, proportion, t-test and binary logistic regression was used for analysis. SPSS version 26 was used to analyze data and p< 0.05 was considered statistically significant. Out of 115 participants 61(53.04%) were females and the mean age of all participant was 9.67 ± 3.07. In SCD group females were 35(53.38%) with the mean age of 9.39 ±3.04. In children with no SCD majority were males 30(55.56%) with mean age of 9.95±3.09. Prevalence of impaired lung function among children with SCD was 52.5% and for non SCD group was 10.72%. Factors significantly associated with impaired lung function were low fetal hemoglobin (AOR=0.878, 95%CL [0.779, 0.989], p=0.0326), low blood pressure (AOR=0.196, 95%CL [0.069, 0.960], p=0.0311) older age at starting SCD clinic (AOR=2.220, 95%CL [1.780, 4.332], p=0.0169) and older age of the child 2. 908[1.220, 16.554], p=0.0367. Lung function impairment is prevalent in Tanzanian children with SCD as compared to their counterparts with predominance of restrictive pattern. Early screening of lung function is of significance especially to those with risk factors in order to diagnose them early and plan interventions for management and prevention