Master Dissertations

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Browsing Master Dissertations by Subject "Abnormal vaginal discharge"

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    Clinical presentations, common microbial isolates and antibiotic susceptibility in women with abnormal vaginal discharge attending gynaecological clinic at Iringa regional referral hospital
    (The University of Dodoma, 2022) Kushoka, Patrick J.
    Abnormal vaginal discharge in women of reproductive age is common with regards of increase in quantity, change in consistency, odour and colour brought about by sexually and non-sexually transmitted infections. This study determined clinical presentation, microbial isolates and their antibiotic susceptibility in women presenting with abnormal vaginal discharge attending gynaecological clinic at Iringa regional referral hospital, Tanzania. Hospital cross-sectional prospective study was carried on women of reproductive age presenting with abnormal vaginal discharge. Convenient-purposive sampling technique was used to sample 346 individuals attending gynaecological clinic during the period of study. Data were analysed using SPSS version 25. Out of 346 women, 292 (84.4%) had infectious pathogen with mean age of 33.5 +/-8.4 years, 173 (50.0%) had educational level below secondary school, 246 (71.1%) were married and 176 (50.9% were grand multiparous. Among women of abnormal vaginal discharge, 176 (50.9%) had creamy whitish vaginal discharge, 265 (76.6%) had no foul-odour. Microbial isolates, G. vaginalis was common by 110 (31.8%), 81 (23.4%) were C. albicans, 47 (13.6%) were N. gonorrhoea, 28 (8.1%) were T. vaginalis and 26 (7.5%) were C. trachomatis. Predictor of antibiotic susceptibility were marital status, education, comorbid conditions and contraceptive use. Completely resistance to penicillin group was observed in all bacterial isolates, 11/47 (61.1%) resistant to cephalosporin and resistance to ciprofloxacin was 3/4 (75%) against N. gonorrhoea. The proportion of women with AVD related to infectious pathogens is raising with drug resistance among recommended antibiotics in syndromic approach becoming significant. Therefore, point-of-care approach is needed to compliment the management regime. Amikacin and Azithromycin can be considered as excellent first-line regime as increasing resistance rate of ciprofloxacin and cephalosporin challenges the use of these antibiotics in the syndromic algorithm for vaginal discharge syndrome.