Ayom, Gwaza EricMalima, Nyemaga MasanjeOwonubi, Shesan JohnRevaprasadu, Neerish2023-05-222023-05-222023Ayom, G. E., Malima, N. M., Owonubi, S. J., & Revaprasadu, N. (2023). Aquasomes: a novel nanocarrier system for drug delivery. In Advanced Nanoformulations, Theranostic Nanosystems, 3: 281-301. Academic Press.DOI: https://doi.org/10.1016/B978-0-323-85785-7.00018-8http://hdl.handle.net/20.500.12661/3786Abstract. Full text book chapter available at https://doi.org/10.1016/B978-0-323-85785-7.00018-8Aquasomes are three layered self-assembled nanoparticles that are emerging as drug carriers or systems for the delivery of drugs. They are composed of an inner core which is usually coated with a polyhydroxyl carbohydrate and a loaded drug. The solid nanocrystalline inner core provides the structural stability of the aquasomes while the carbohydrate coat shields the loaded drug against dehydration. These self-assembled particles maintain the conformational integrity of the loaded drugs and hence have been exploited as carriers of drugs including insulin, hemoglobin, oxygen, antigens, and antibodies. This system of drug delivery has also been shown to improve the solubility of poorly soluble drugs. This chapter presents aquasomes’ preparation, properties, applications, and potential as drug carriers.enBioactive agentOuter layerInner core materialDrug vehiclesAquasomesDrug deliveryNanocarrier systemNanoparticlesDrug carriersDrug deliveryBook chapter