Browsing by Author "Luanda, Amos"

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    Ethnomedicinal uses, phytochemistry and pharmacological study of Ocimum americanum L.: A review
    (Elsevier, 2023) Luanda, Amos; Ripanda, Asha; Sahini, Mtabazi G.; Makangara, John J.
    Background: Ocimum americanum L., commonly known as Hoary basil, is a wild aromatic shrub traditionally used to treat different ailments. Its leaves, flowers and aerial parts have been widely studied to evaluate its medicinal potential such as lowering blood pressure, treatment of microbial infections, malaria, cold, liver and eye problems. Purpose: This study aims to provide an in-depth review of ethnomedicinal uses, phytochemistry, and pharmacological activities of O. americanum, to evaluate its benefits, challenges and potential future prospects. Methods: All the information about O. americanum was collected from various platforms, including google scholar, PubMed, ScienceDirect, plants of the world online and Research4Life. The acceptance criteria of the collected information based on the PICOS model. The GRADE approach was used to analyze and evaluate the quality of the collected information. Results: This study showed that O. americanum has tremendous therapeutic potential to be integrated into mainstream medical practice to manage various medical conditions. The inconsistence of the phytoconstituents among the plant parts resulted in a significant variation of pharmacological activities. Plant originality, genetic variability and extraction techniques are among the factors contributing to the variation of phytoconstituents that are responsible for pharmacological activities. Conclusion: This study revealed that O. americanum is a potential medicinal plant for mitigating various medical conditions. However, future study should continue to focus on the bioactive compounds and their mechanisms of action. Additionally, the utilization of the O. americanum for the development of drugs as well as quality evaluation in clinical settings are highly recommended.
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    Recent trend on Tetradenia riparia (Hochst.) Codd (Lamiaceae) for management of medical conditions
    (Elsevier, 2023) Luanda, Amos; Ripanda, Asha
    Tetradenia riparia (Hochst.) Codd (Lamiaceae) is a medicinal plant traditionally utilized to manage various transmitted and non-transmitted diseases such as HIV/AIDS, malaria, respiratory problems and diabetes. All parts of this plant have been utilized and demonstrated a positive promise for managing medical conditions. Several studies have been conducted to evaluate its pharmacological potentials, such as antibacterial, anthel-mintic, larvicidal, antifungal, antileishmanial, antioxidant and insecticidal activities. Purpose: This review aims to address the potential of T riparia for managing medical conditions, challenges and future research directions. In particular, the bioactive compounds responsible for pharmacological properties are discussed. The well-explained relevant studies and the most appropriate studies based on the selected topic were chosen. The obtained information was analyzed to determine the outcome by screening sources by title, abstract, and whole work. The selected studies were chosen in an agreement between the authors. The relevant information was sorted systematically into titles and subtitles and compressively discussed. The information presented in this review is obtained from various online platforms such as Google scholar, Springer, ScienceDirect, Web of Science and PubMed by searching using specific terms and phrases. The selected works based on the inclusion criteria as agreed by all authors. The phytochemical profile of T. riparia revealed the presence of several phytoconstituents, which support the pharmacological potentials of the plant. Findings revealed that both T. riparia essential oil and extracts have significant medicinal potentials remarkable for mitigating medical conditions, but the former outperforms the latter in terms of pharmacological potentials. Additionally, T. riparia has potential prospects in major medical conditions like tuberculosis, diabetes, malaria, snake bites, gonorrhea, dental abscesses, gastroenteritis, diar-rhoea, etc.This study revealed that Tetradenia riparia is a promising medicinal plant that can be employed as an alternative medicine against various medical conditions.
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    Therapeutic potential of Equisetum arvense L. for management of medical conditions
    (Elsevier, 2023) Luanda, Amos; Ripanda, Asha; Makangara, John J.
    Background: Equisetum arvense L. has a long history of use in traditional medicines for treating ailments like digestive, inflammatory, respiratory and urinary disorders. Researchers have been focused on developing drugs from natural sources particularly the medicinal plants for global mitigation of medical conditions while protecting the environment. The use of natural products is one of the strategies that the WHO recommended to manage global medical conditions. The interest to use natural remedies as alternative medicines for management of medical conditions is increasing considerably. Purpose: This review intended to discuss the therapeutic potential of E. arvense for the mitigation of various diseases by providing up-to-date information on its benefits, challenges and potential future opportunities. Methods: The information is collected and systematically analysed from various online databases including Google scholar, ScienceDirect, Springer, Web of Science, PubMed and Plant of the World Online. Results: This study demonstrated the enormous therapeutic potential of E. arvense for the management of various ailments. The significant changes in the phytoconstituents amongst the plant parts have been observed, which correspond to the variation in its pharmacological properties. Several pharmacological activities of E. arvense such as anticancer, anti-inflammatory, antibacterial, antifungal and antidiabetics support its traditional uses. Conclusion: E. arvense has a lot of therapeutic promises for treating a number of health disorders. The extension of its clinical study requires further identification of the bioactive compounds, their modes of action as well as toxicological study. The existing therapeutic potential of E. arvense, suggesting that it is a suitable medicinal plant for management of medical conditions.