Adrenal insufficiency: A forgotten diagnosis in HIV/AIDS patients in developing countries

Simple item page
dc.contributor.authorNassoro, David D
dc.contributor.authorMwakyula, Issakwisa Habakkuk
dc.contributor.authorMkhoi, Mkhoi L
dc.contributor.authorSabi, Issa
dc.contributor.authorMerem, Alfred J.
dc.contributor.authorLawal, Paul S
dc.date.accessioned2020-09-02T06:49:24Z
dc.date.available2020-09-02T06:49:24Z
dc.date.issued2019
dc.descriptionFull-text article. Also available at https://doi.org/10.1155/2019/2342857en_US
dc.description.abstractAdrenal insufficiency (AI) is one of the most common endocrine diseases in patients with HIV/AIDS, leading to high morbidity and mortality in HIV patients who become critically ill. Various etiologies are associated with the condition, including cytomegalovirus (CMV), Mycobacterium tuberculosis, lymphoma, Kaposi’s sarcoma, and drugs such as rifampin, among others. HIV patients with advanced disease develop relative cortisol deficiency largely due to the reduction of cortisol reserve, which predisposes patients to the adrenal crisis in periods of stress or critical illness. The prevalence of AI in HIV/AIDS patients during HAART era is higher in developing than developed countries, probably due to limited access to both diagnosis and adequate treatments which increases the risk of opportunistic infections. The clinical features of functional adrenal insufficiency in HIV/AIDS patients can be masked by various infectious, noninfectious, and iatrogenic causes, which reduce clinical recognition of the condition. Development of simple screening algorithms may help clinicians reach the diagnosis when approaching these patients. In many low-income countries, most HIV patients are diagnosed with advanced disease; thus, further research is necessary to elucidate the prevalence of adrenal insufficiency in HIV/AIDS patients and the condition’s impact on mortality in this population.en_US
dc.identifier.citationNassoro, D. D., Mkhoi, M. L., Sabi, I., Meremo, A. J., Lawala, P. S., & Mwakyula, I. H. (2019). Adrenal insufficiency: a forgotten diagnosis in HIV/AIDS patients in developing countries. International Journal of Endocrinology, 1-9.en_US
dc.identifier.otherDOI: 10.1155/2019/2342857
dc.identifier.urihttp://hdl.handle.net/20.500.12661/2462
dc.language.isoenen_US
dc.publisherHindawien_US
dc.subjectAdrenal insufficiencyen_US
dc.subjectHIV patientsen_US
dc.subjectHIV/AIDS Patientsen_US
dc.subjectEndocrine diseasesen_US
dc.subjectCortisol deficiencyen_US
dc.subjectHuman ImmunodeficiencyVirusen_US
dc.subjectAcquired Immunodeficiency Syndromeen_US
dc.subjectHIVen_US
dc.subjectAIDSen_US
dc.subjectEndocrine diseasesen_US
dc.titleAdrenal insufficiency: A forgotten diagnosis in HIV/AIDS patients in developing countriesen_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
NASSORO.pdf
Size:
1.56 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Journal Articles