Polylactic acid (PLA)-based materials: a review on the synthesis and drug delivery applications

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dc.contributor.authorSahini, Mtabazi G.
dc.date.accessioned2024-08-19T07:03:06Z
dc.date.available2024-08-19T07:03:06Z
dc.date.issued2023
dc.descriptionAbstract. Full-text available at https://doi.org/10.1007/s42247-023-00551-7
dc.description.abstractControlled drug release is an important aspect of biomedical applications of polymer materials. Polylactic acid (PLA)-based materials have been thoroughly researched for biomedical applications, owing to their attractive properties. Here, the advancements in the preparation and application of PLA-based polymers for drug delivery are reviewed. In addition to discussing the potentials of the PLA-based materials for drug delivery, the production techniques and various geometries of the drug carriers are also covered. The review has established that several drugs, including ibuprofen, amphotericin B, paclitaxel, 5-fluorouracil, doxorubicin, ketoprofen, rifampicin, salinomycin, ciprofloxacin, and ornidazole, have been successfully loaded into and released from PLA-based materials. Due to the hydrophobic nature of PLA, its modification to accommodate both the hydrophobic and hydrophilic drugs is emphasized in the literature.
dc.identifier.citationSahini, M. G. (2023). Polylactic acid (PLA)-based materials: a review on the synthesis and drug delivery applications. Emergent Materials, 6(5), 1461-1479.
dc.identifier.doi10.1007/s42247-023-00551-7
dc.identifier.otherDOI: 10.1007/s42247-023-00551-7
dc.identifier.urihttps://repository.udom.ac.tz/handle/20.500.12661/4772
dc.language.isoen
dc.publisherSpringer Science and Business Media LLC
dc.relation.ispartofEmergent Materials
dc.subjectControlled drug release
dc.subjectBiomedical applications
dc.subjectPolylactic acid (PLA)
dc.subjectDrug delivery
dc.subjectPLA-based polymers
dc.subjectProduction techniques
dc.subjectDrug carriers
dc.subjectIbuprofen
dc.subjectAmphotericin B
dc.subjectPaclitaxel
dc.subject5-fluorouracil
dc.subjectDoxorubicin
dc.subjectKetoprofen
dc.subjectRifampicin
dc.subjectSalinomycin
dc.subjectCiprofloxacin
dc.subjectOrnidazole
dc.subjectHydrophobic drugs
dc.subjectHydrophilic drugs
dc.subjectPLA modification.
dc.titlePolylactic acid (PLA)-based materials: a review on the synthesis and drug delivery applications
dc.typeArticle
oaire.citation.issue5
oaire.citation.volume6
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