Process development of the synthesis of 2, 3-dichlorophenylpiperazine

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dc.contributor.authorHiji, Morris Frank
dc.contributor.authorZheng, GuoJun
dc.contributor.authorYuan, QiPeng
dc.date.accessioned2020-03-19T07:03:58Z
dc.date.available2020-03-19T07:03:58Z
dc.date.issued2007
dc.descriptionFull Text Article. Also available at: https://www.researchgate.net/profile/Morris_Hiji/publication/307594087_Process_development_of_the_synthesis_of_2_3-dichlorophenylpiperazine/links/57cb448808ae59825183599f.pdfen_US
dc.description.abstractThe new pathway for the synthesis of 2, 3-dichlorophenylpiperazine from cheap raw material, 2, 3-dichloroaniline is presented. The hydrogen sulphate salt of 2, 3-dichloroaniline was converted to the corresponding Aryl Iodide in good yield of 81 % by reacting with conc. H2SO4 and NaNO2 to form intermediate diazonium salt, which was further displaced by Kl. The desired product was obtained by reacting Aryl Iodide and piperazine in the presence of CuI as catalyst, proline as ligand, K2C03 as base and dimethyl sulfoxide as solvent with yield of 20 % . The method is simple, utilizes cheap catalyst and ligand, insensitive to moisture; it is easy to separate the product, and can undergo large-scale production.en_US
dc.identifier.citationHiji, M. F., Zheng G., & Yuan, Q. (2007). Process development of the synthesis of 2, 3-dichlorophenylpiperazine. Journal of Beuing University of Chemical Technology, 34(4).en_US
dc.identifier.urihttp://hdl.handle.net/20.500.12661/2181
dc.language.isoenen_US
dc.publisherBeijing University of Chemical Technologyen_US
dc.subject2, 3-dichlorophenylpiperazineen_US
dc.subject2, 3-dichloroanilineen_US
dc.subjectDiawnium salten_US
dc.subject1, 2-dichloro-3-iodobenzeneen_US
dc.subjectHydrogen sulphate salten_US
dc.subjectAryl iodideen_US
dc.titleProcess development of the synthesis of 2, 3-dichlorophenylpiperazineen_US
dc.typeArticleen_US
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