Overexpression of Epidermal Growth Factor Receptor (EGFR) in Esophageal Squamous Cell Carcinoma and Its Correlation with Clinicopathological Characteristics in Central Uganda

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dc.contributor.authorMunema, Asafu M.
dc.contributor.authorYahaya, James J.
dc.contributor.authorLukande, Robert
dc.contributor.authorKalungi, Sam
dc.date.accessioned2020-08-25T09:00:50Z
dc.date.available2020-08-25T09:00:50Z
dc.date.issued2019
dc.descriptionFull-text article. Also available at http://journaljcti.com/index.php/JCTI/article/view/30098en_US
dc.description.abstractThe aims of the current study were to determine the prevalence of epidermal growth factor (EGFR) receptor in patients diagnosed with oesophagal squamous cell carcinoma (ESCC) as well as assessing the correlation of overexpression of EGFR with age, gender and tumour grades of the cases. This was a cross-sectional analytical study. The study was conducted in the pathology laboratory at the department of pathology, Makerere College of Health Sciences, Kampala-Uganda for five months. A sample of 127 archival tissue blocks from patients with ESCC diagnosed between 2010 and 2012 was retrieved from the tissue repository and used to assess overexpression of EGFR using monoclonal mouse Anti-human wild type EGFR antibody. For the association between age and overexpression of EGFR, Kruskal- Wallis H test was used and for tumour grade and sex and EGFR, Chi-Square test was performed using SPSS version 16.0. P ˂ .05 was considered statistically significant. The age range of the patients with ESCC in this study was 35-99 years with a mean of 59.55 years. The peak age of the cases was 55-64 years. Males and females were 68.5% and 31.5% respectively. Moderately differentiated tumours dominated by comprising 59.9%. The prevalence of overexpression of EGFR was 61.4%. The highest overexpression of EGFR was seen in cases with grade 2 compared to grade 1 and 3 but not statistically significant (P = .255). Overexpression of EGFR was relatively higher in cases with age ≥ 50 years, but the difference was not statistically significant (P = .931). Males expressed relatively higher EGFR than females, however, the difference was not statistically significant (P = .944). Majority of patients with ESCC in Uganda have moderately differentiated tumour and a significant number of them tend to show overexpression of EGFR antigen.en_US
dc.identifier.citationMunema, A. M., Yahaya, J. J., Lukande, R., & Kalungi, S. (2019). Overexpression of Epidermal Growth Factor Receptor (EGFR) in Esophageal Squamous Cell Carcinoma and Its Correlation with Clinicopathological Characteristics in Central Uganda. Journal of Cancer and Tumor International, 1-10.en_US
dc.identifier.otherURL: http://journaljcti.com/index.php/JCTI/article/view/30098
dc.identifier.urihttp://hdl.handle.net/20.500.12661/2411
dc.language.isoenen_US
dc.publisherScienceDomain Internationalen_US
dc.subjectOverexpressionen_US
dc.subjectEpidermal Growth Factor Receptoren_US
dc.subjectEGFRen_US
dc.subjectEsophageal squamous cell carcinomaen_US
dc.subjectESCCen_US
dc.subjectUgandaen_US
dc.subjectSquamous cell carcinomaen_US
dc.titleOverexpression of Epidermal Growth Factor Receptor (EGFR) in Esophageal Squamous Cell Carcinoma and Its Correlation with Clinicopathological Characteristics in Central Ugandaen_US
dc.typeArticleen_US
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