Prevalence and factors associated with cholelithiasis in children with sickle cell disease attending the sickle cell clinic at Dodoma Regional Referral Hospital
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Date
2023
Authors
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Journal ISSN
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Publisher
The University of Dodoma
Abstract
Background: Cholelithiasis also known as Gallstones are a common consequence of
chronic hemolysis in Sickle Cell Disease (SCD) and its variants. In our settings
majority of children comes with cholecystitis which is one of the complication of
cholelithiasis, but the real burden of cholelithiasis is not well. The purpose of this
study was to determine the prevalence of cholelithiasis and associated factors in
children with SCD in Dodoma.
Methods: This was a hospital based cross-sectional study of 180 children aged 2 to
17years, from January 2023 to June 2023 (a period of 6 months) at Dodoma Regional
Referral Hospital. Socio-demographic, clinical and laboratory data were collected
using a semi structured questionnaire. Cholelithiasis was defined as curvilinear
echogenic structures casting acoustic shadow in the liver which moved with a change
in scan position by using a Phillips HD3 general purpose ultrasound scanner. Data
analysis was done using SPSS version 25 and statistical significance was assumed
for factors with p-value<0.05.
Results: A total of 180 children were enrolled. Most of the enrolled children were
males 112(62.22%). The mean age was 6.89±3.8 years ranging from 2 to 17 years.
The prevalence of cholelithiasis was 12.22% (22 children) and age range between
10-17 years (AOR=6.831, CI [1.360, 34.326], p-value =0.0197), female sex AOR=
9.471, CI [2.271, 39. 507], p-value =0.0197), blood transfusion more than once in the
past one year (AOR=5.959, CI [1.689, 21.023], p-value 0.0055), family history of
gallstones (AOR=15.244, CI [1.565, 148.487], p-value 0.0190) and hepatomegaly
(AOR=16.778, CI [3.140,89.655],p-value 0.0010) were factors independently
associated with Cholelithiasis.
Conclusion: Cholelithiasis is a common complication warranting regular screening
among children with SCD attending clinic in Dodoma. Female sex, children aged
between 10-17 years, blood transfusion more than once in a year, those with family
history of gallstones and presence of hepatomegaly were more likely to have
cholelithiasis
Description
Dissertation (Msc Medicine)
Keywords
cholelithiasis, sickle cell disease, sickle cell clinic, Dodoma Regional Referral Hospital
Citation
Mfugale, Z. (2023). Prevalence and factors associated with cholelithiasis in children with sickle cell disease attending the sickle cell clinic at Dodoma Regional Referral Hospital, (Master's Dissertation). The University of Dodoma.