Geranylbenzoquinonoids from Lettowianthus stellatus fruits

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dc.contributor.authorMakangara, John J.
dc.contributor.authorNkunya, Mayunga H.H.
dc.contributor.authorJonker, Stephan S.
dc.date.accessioned2023-05-23T12:36:25Z
dc.date.available2023-05-23T12:36:25Z
dc.date.issued2010
dc.descriptionAbstract. Full text article available at https://doi.org/10.1080/14786410802573693en_US
dc.description.abstractThe geranylbenzoquinonoids 7-(3,7-dimethylocta-2,6-dienyl)-5-hydroxy-3H-benzofuran-2-one (lettowienolide), dimethyl 2,3-bis-[5-(3,7-dimethylocta-2,6-dienyl)-3,6-dioxocyclohexa-1,4-dienyl]-succinate (lettowiquinone), 2-(3,7-dimethylocta-2,6-dienyl)-6-[7-(3,7-dimethylocta-2,6-dienyl)-5-hydroxybenzofuran-2-yl]-[1,4]benzoquinone (lettowifuraquinone), methyl [3-(3,7-dimethylocta-2,6-dienyl)-6-methyl-5-(3-methylbut-2-enyl)-1,4-dioxo-1,5, 8,8a-tetrahydro-4H-nathphalen-4a-yl)]-acetate (lettowinone) and methyl [6-hydroxy-2-methyl-2-(4-methylpent-3-enyl)-2H-chromen-8-yl]-acetate (lettowipyraquinol) were isolated from fruits of Lettowianthus stellatus Diels, together with juvenile hormone III and 7-octadecen-9-ynoic acid. Lettowienolide and lettowiquinone exhibited mild in vitro activity against the Plasmodium falciparum malaria parasite (each IC50 ∼ 20 µg mL−1). Structural determination was achieved based on extensive analysis of spectroscopic data.en_US
dc.identifier.citationMakangara, J. J., Nkunya, M. H., & Jonker, S. S. (2010). Geranylbenzoquinonoids from Lettowianthus stellatus fruits. Natural Product Research, 24(8), 710-717.en_US
dc.identifier.otherDOI: https://doi.org/10.1080/14786410802573693
dc.identifier.urihttp://hdl.handle.net/20.500.12661/3864
dc.language.isoenen_US
dc.publisherTaylor & Francisen_US
dc.subjectGeranylbenzoquinonoidsen_US
dc.subjectLettowianthus stellatusen_US
dc.subjectLettowianthus stellatus fruitsen_US
dc.subjectPlasmodium falciparumen_US
dc.subjectLettowienolideen_US
dc.subjectLettowiquinoneen_US
dc.subjectAnnonaceaeen_US
dc.subjectMalaria parasiteen_US
dc.subjectMalariaen_US
dc.titleGeranylbenzoquinonoids from Lettowianthus stellatus fruitsen_US
dc.typeArticleen_US
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