Prevalence and factors associated with antipsychotics-induced movement disorders among admitted patients at Mirembe hospital
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Date
2022
Authors
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Journal ISSN
Volume Title
Publisher
The University of Dodoma
Abstract
Antipsychotic-induced movement disorders can cause distress in patients which can lead to non-compliance with antipsychotic treatment, relapses, shame, stigma, and even death in severe cases. Antipsychotics have been of paramount importance when treating mental disorders, as they are associated with a reduction in the severity of serious mental disorders and improve patients' outcomes. However, antipsychotics produce various side effects among which are movement disorders such as antipsychotic-induced Parkinsonism, tardive dyskinesia, dystonia, and Akathisia. Despite having all these unwanted side effects at the Mirembe Mental Health Hospital (MMHH) which is the only one of its kind in the country, no formal study has been done to quantify the magnitude of the movement disorders and identify the factors associated with them. This study aimed to determine the prevalence and risk factors of antipsychotics-induced movement disorders among patients admitted at the MMHH. A cross-sectional study was conducted from May to July 2022 at MMHH. A consecutive sampling method was used to select 287 participants. The extrapyramidal symptoms rating scale (ESRS) was used to identify participants with antipsychotic-induced movement disorders. Univariate and multivariable logistic regression was used to assess factors associated with antipsychotic-induced movement disorders. The prevalence of antipsychotics-induced movement disorders was 46.3% whereby, antipsychotics-induced Parkinsonism was 15%, antipsychotics-induced Tardive Dyskinesia was 33.4%, while antipsychotics-induced Akathisia and antipsychotics-induced dystonia were 23.7% and 11.1% respectively. Duration of illness (AOR 4.476[1.789, 11.201], p=0.0014) and Phenobarbital combined with Haloperidol or Chlorpromazine (AOR 0.333[0.136, 0.814], p=0.0159) were among the statistically significant factors associated with movement disorders. This study revealed that antipsychotics-induced movement disorders are a significant problem among admitted patients at MMHH affecting around 46.3%. Duration of illness and Phenobarbital combined with Haloperidol or Chlorpromazine was among the factors associated with movement disorders. Healthcare providers at MMHH need to follow guidelines and prescribe antipsychotics accordingly to reduce the occurrences of antipsychotic-induced movement disorders.
Description
MMED Psychiatry
Keywords
Antipsychotics-induced movement disorders, Antipsychotics, Dodoma, Antipsychotic treatment, AIMDs, Mirembe Mental Health Hospital, MMHH, Akathisia
Citation
Mwisomba, G. L. (2022). Prevalence and factors associated with antipsychotics-induced movement disorders among admitted patients at Mirembe hospital (Master didssertation). The University of Dodoma, Dodoma.