High incidence of poor in-hospital outcomes of term newborns with hypoxic–ischaemic encephalopathy admitted at a regional referral hospital in Dodoma, Tanzania
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Date
2022
Journal Title
Journal ISSN
Volume Title
Publisher
Wiley Online Library
Abstract
Hypoxic–ischaemic encephalopathy (HIE) is one of the leading causes of neonatal deaths and neurological impairment with the highest impact in resource-limited settings. This study aimed to determine the incidence of poor in-hospital outcomes and related factors among newborns with HIE in Tanzania.
Methods
A prospective observational study in which 170 newborns with HIE (diagnosed using the Thompson clinical score) were followed from 1 September 2020 to 28 February 2021 at the neonatal ward of Dodoma Regional Referral Hospital in Dodoma, central Tanzania, until discharge or death. Clinical parameters were recorded. Multinomial logistic regression analysis was applied to determine factors associated with adverse outcomes.
Results
Out of 170 newborns, 44.7% (76/170) had poor outcomes (death 27.1% (46/170); neurological deficits 17.6% (30/170)). Severe HIE (Thompson score > 14) (p < 0.0001), history of aspiration (adjusted odds ratio (AOR) = 3.06, 95% confidence interval (CI) [1.170, 8.014], p = 0.0226) and 5th-min APGAR of <7 (AOR = 2.88, 95% CI [1.133, 7.310], p = 0.0262) were associated with mortality. Severe HIE, delivery at other facilities (AOR = 3.106 CI [1.158, 8.332], p = 0.0244) and abnormal heart rate (<100 or ≥160 beats/min) on admission (AOR = 3.469 [1.200, 10.030], p = 0.0216) predicted neurological impairment at discharge.
Conclusion
Hypoxic–ischaemic encephalopathy is associated with a high incidence of poor outcomes in resource-limited settings. To improve outcomes newborns with severe HIE, history of aspiration, referred from other facilities, 5th-min APGAR score of <7 and abnormal heart rate need improved quality of neonatal care.
Description
Abstract. Full Text Article available at: https://doi.org/10.1111/apa.16592
Keywords
Hypoxic–ischaemic encephalopathy, HIE, Neonatal deaths, Newborns deaths, In-hospital outcomes, Neurological impairment
Citation
Mwatonoka, J. F., Jumanne, S., & Nyundo, A. (2022). High incidence of poor in-hospital outcomes of term newborns with hypoxic–ischaemic encephalopathy admitted at a regional referral hospital in Dodoma, Tanzania. Acta Paediatrica. https://doi.org/10.1111/apa.16592