Modelling african trypanosomiasis in human with optimal control and cost-effectiveness analysis

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dc.contributor.authorGervas, Hamenyimana Emanuel
dc.contributor.authorHugo, Alfred K.
dc.date.accessioned2022-11-30T07:16:56Z
dc.date.available2022-11-30T07:16:56Z
dc.date.issued2021
dc.descriptionFull Text Article. Also Available at: http://doi.org/10.14317/jami.2021.895en_US
dc.description.abstractHuman African Trypanosomiasis (HAT) also known as sleeping sickness, is a neglected tropical vector borne disease caused by trypanosome protozoa transmitted by bites of infected tsetse fly. The basic reproduction number, R0 derived using the next generation matrix method which shows that the disease persists in the population if the value of R0 > 1. The numerical simulations of optimal control model carried out to determine the control strategy that can combat HAT under the minimum cost. The results indicate that, the use of both education campaign, treatment and insecticides are more efficient and effective to eliminate HAT in African community but too costly. Furthermore, the cost-effectiveness of the control measures (education campaign, treatment and insecticides) were determined using incremental cost-effectiveness ratio (ICER) approach and the results show that, the use of education and treatment of infected people as the best cost effective strategy compared to other strategies.en_US
dc.identifier.citationGervas, H. E. & Hugo, A. K. (2021). Modelling african trypanosomiasis in human with optimal control and cost-effectiveness analysis . Journal of applied mathematics & informatics, 39(5_6), 895-918.en_US
dc.identifier.issnDOI: http://doi.org/10.14317/jami.2021.895
dc.identifier.urihttp://hdl.handle.net/20.500.12661/3569
dc.language.isoenen_US
dc.publisherThe Korean Society for Computational and Applied Mathematicsen_US
dc.subjectHuman African Trypanosomiasisen_US
dc.subjectHATen_US
dc.subjectSleeping sicknessen_US
dc.subjectTropical vectoren_US
dc.subjectTrypanosome protozoaen_US
dc.subjectTropical diseaseen_US
dc.subjectTsetse flyen_US
dc.titleModelling african trypanosomiasis in human with optimal control and cost-effectiveness analysisen_US
dc.typeArticleen_US
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