Pattern, clinical characteristics, and outcome of meningitis among HIV-infected adults admitted in a tertiary hospital in North western Tanzania: a cross-sectional study

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dc.contributor.authorBoaz, Matobogolo M.
dc.contributor.authorKalluvya, Samuel
dc.contributor.authorDowns, Jennifer A.
dc.contributor.authorMpondo, Bonaventura C. T.
dc.contributor.authorMshana, Stephen E.
dc.date.accessioned2021-05-18T09:15:56Z
dc.date.available2021-05-18T09:15:56Z
dc.date.issued2016
dc.descriptionFull text article. Also available at http://dx.doi.org/10.1155/2016/6573672en_US
dc.description.abstractLimited information exists on the etiologies, clinical characteristics, and outcomes of meningitis among HIV-infected patients in Africa. We conducted a study to determine the etiology, clinical characteristics, and outcomes of meningitis among HIV-infected adults. Methods. A prospective cross-sectional hospital based study was conducted among HIV-infected patients aged ≥18 years admitted to the medical wards with symptoms and signs of meningitis. Sociodemographic and clinical information were collected using a standardized data collection tool. Lumbar puncture was performed to all patients; cerebrospinal fluid samples were sent for analysis. Among 60 HIV-infected adults clinically diagnosed to have meningitis, 55 had CSF profiles consistent with meningitis. Of these, 14 (25.5%) had a laboratory-confirmed etiology while 41 (74.5%) had no isolate identified. Cryptococcus neoformans was the commonest cause of meningitis occurring in 11 (18.3%) of patients followed by Mycobacterium tuberculosis (6.7%). The in-hospital mortality was 20/55 (36.4%). Independent predictors of mortality were low baseline CD4 count and turbid CSF appearance. Cryptococcal meningitis is the most prevalent laboratory-confirmed etiological agent among adult HIV-infected patients with suspected meningitis admitted to medical wards in Western Tanzania. Mortality rate in this population remains unacceptably high. Improving diagnostic capacity and early treatment may help to decrease the mortality rateen_US
dc.identifier.citationBoaz, M. M., Kalluvya, S., Downs, J. A., Mpondo, B. C., & Mshana, S. E. (2016). Pattern, clinical characteristics, and outcome of meningitis among HIV-infected adults admitted in a tertiary hospital in north western Tanzania: A cross-sectional study. Journal of tropical medicine, 2016.en_US
dc.identifier.otherDOI: http://dx.doi.org/10.1155/2016/6573672
dc.identifier.urihttp://hdl.handle.net/20.500.12661/3120
dc.language.isoenen_US
dc.publisherHindawi Publishing Corporationen_US
dc.subjectMeningitisen_US
dc.subjectAdults HIV-infecteden_US
dc.subjectMycobacterium tuberculosisen_US
dc.subjectTuberculosisen_US
dc.subjectCryptococcal meningitisen_US
dc.subjectHuman Immunodeficiency Virusen_US
dc.subjectTBen_US
dc.titlePattern, clinical characteristics, and outcome of meningitis among HIV-infected adults admitted in a tertiary hospital in North western Tanzania: a cross-sectional studyen_US
dc.typeArticleen_US
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