Prevalence and risk factors of active TB among adult HIV patients receiving ART in Northwestern Tanzania: a retrospective cohort study

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dc.contributor.authorGunda, Daniel W.
dc.contributor.authorMaganga, Simon C.
dc.contributor.authorNkandala, Igembe
dc.contributor.authorKilonzo, Semvua B.
dc.contributor.authorMpondo, Bonaventura C.
dc.contributor.authorShao, Elichilia R.
dc.contributor.authorKalluvya, Samwel E.
dc.date.accessioned2021-05-26T06:56:28Z
dc.date.available2021-05-26T06:56:28Z
dc.date.issued2018
dc.descriptionFull text article. Also available at https://doi.org/10.1155/2018/1346104en_US
dc.description.abstractAlthough ART has improved the outcome of people living with HIV/AIDS, still some patients develop TB while receiving ART. The literature on the magnitude of this problem is still scarce in our setting especially northwestern Tanzania. This study was designed to determine the prevalence of active TB among HIV patients on ART and assess its potential risk factors. A retrospective cohort study was done among adult HIV-positive patients initiated on ART at Bugando Medical Centre. Patients who were TB positive before ART initiation were excluded. Data regarding demographic, clinical, and laboratory information, TB status on receipt of ART, and time on ART were collected and analyzed using STATA 11 to determine the prevalence of TB and its associated factors. In total, 391 patients were enrolled in this study. The median age was 39 (32–46) years, and a total of 129 (32.99%) participants had CD4 counts <200 cells/µl and 179 (45.78%) had WHO stage 3 and 4 illnesses. A total of 43 (11.0%) participants developed TB while receiving ART which was independently associated with male gender (OR = 2.9;p=0.007 ), WHO clinical stage 3 and 4 (OR = 1.4; p=0.029), baseline CD4 count <200 cells/µl (OR = 9.1; pp<), and having not used IPT (OR = 3.1; p=0.05). Active TB is prevalent among HIV patients while receiving ART in northwestern Tanzania which is independently associated with male gender, advanced HIV disease, and nonuse of IPT. Universal HIV testing could reduce late HIV diagnosis and hence reduce the risk of developing TB while receiving ART in our setting. Also IPT should be widely used for those who are negative for TB on screening.en_US
dc.identifier.citationGunda, D. W., Maganga, S. C., Nkandala, I., Kilonzo, S. B., Mpondo, B. C., Shao, E. R., & Kalluvya, S. E. (2018). Prevalence and risk factors of active TB among adult HIV patients receiving ART in northwestern Tanzania: a retrospective cohort study. Canadian Journal of Infectious Diseases and Medical Microbiology, 2018.en_US
dc.identifier.otherDOI: https://doi.org/10.1155/2018/1346104
dc.identifier.urihttp://hdl.handle.net/20.500.12661/3214
dc.language.isoenen_US
dc.publisherHindawien_US
dc.subjectActive TBen_US
dc.subjectTBen_US
dc.subjectAdult HIV patientsen_US
dc.subjectHIVen_US
dc.subjectHuman immunodeficiency virusen_US
dc.subjectAIDSen_US
dc.subjectAcquired immunodeficiency syndromeen_US
dc.subjectTuberculosisen_US
dc.titlePrevalence and risk factors of active TB among adult HIV patients receiving ART in Northwestern Tanzania: a retrospective cohort studyen_US
dc.typeArticleen_US
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