Lipid secretory mechanisms in the mammalian harderian gland
| dc.contributor.author | Satoh, Yohichi | |
| dc.contributor.author | Gesase, Ainory Peter | |
| dc.contributor.author | Habara, Yoshiaki | |
| dc.contributor.author | Ono, Kazuyuki | |
| dc.contributor.author | Kanno, Tomio | |
| dc.date.accessioned | 2022-12-12T08:29:43Z | |
| dc.date.available | 2022-12-12T08:29:43Z | |
| dc.date.issued | 1996 | |
| dc.description | Abstract: Full text article available at https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/abs/10.1002/(SICI)1097-0029(19960601)34:2%3C104::AID-JEMT2%3E3.0.CO;2-S | en_US |
| dc.description.abstract | The mammalian Harderian glands are lipid-secreting glands. In an unstimulated condition, the glandular cells frequently exocytose the lipid materials; however, no intracellular calcium ion ([Ca2+l,) changes are detectable. Cholinergic (muscarinic) secretagogues induce secre tory activity and increase of [Ca2+lc. A Gprotein activator, sodium fluoride, enhances the secretory activity and increase of [Ca2+Ic. Removal of extracellular calcium ions inhibits the secretion en hanced by cholinergic stimulation. Under pharmacologic stimulation, glandular cells may show an apocrine-like secretory pattern. Cholinergic stimulation also induces contraction of the myoepithe lial cells covering glandular end pieces; however, the reduction in volume of glandular end pieces is not prominent. Catecholamines have no effect on the release of lipid materials. These results indicate the involvement of G-proteins linking with muscarinic receptors and Ca2+ dynamics (increase of [Ca2+l, and Ca2+ influx) in lipid secretion by glandular cells and in contraction of myoepithelial cells of mammalian Harderian glands. However, the increase of [Ca2 + I, in Harderian glands was less when compared with other cells-for instance, those which secrete protein. 0 1996 Wiley-Liss, Inc. | en_US |
| dc.identifier.citation | Satoh, Y., Gesase, A. P., Habara, Y., Ono, K., & Kanno, T. (1996). Lipid secretory mechanisms in the mammalian harderian gland. Microscopy research and technique, 34(2), 104-110. | en_US |
| dc.identifier.uri | http://hdl.handle.net/20.500.12661/3578 | |
| dc.language.iso | en | en_US |
| dc.publisher | WILEY-LISS | en_US |
| dc.subject | Mammalian harderian gland | en_US |
| dc.subject | Exocytosis | en_US |
| dc.subject | Cholinergic stimuli | en_US |
| dc.subject | G-protein | en_US |
| dc.subject | Myoepithelial cell | en_US |
| dc.subject | Calcium ion | en_US |
| dc.title | Lipid secretory mechanisms in the mammalian harderian gland | en_US |
| dc.type | Article | en_US |