Antiplasmodial, antimicrobial and cytotoxic activities of extracts from selected medicinal plants growing in Tanzania

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dc.contributor.authorBegum, Sartaz
dc.contributor.authorNyandoro, Stephen S.
dc.contributor.authorMunissi, Joan J. E.
dc.contributor.authorBuriyo, Amelia S.
dc.contributor.authorMakangara, John J.
dc.contributor.authorLucantoni, Leonardo
dc.contributor.authorAvery, Vicky M.
dc.contributor.authorErdelyi, Mate
dc.date.accessioned2023-05-22T13:09:52Z
dc.date.available2023-05-22T13:09:52Z
dc.date.issued2019
dc.descriptionAbstract. Full text article available at https://doi.org/10.1080/22311866.2020.1770125en_US
dc.description.abstractThis paper reports on the evaluation of antiplasmodial, antimicrobial and cytotoxic activities of extracts from eleven plant species traditionally used by some Tanzanian coastal communities for treatment of malaria, microbial infections and related ailments. Crude extracts from selected plant species namely Acacia zanzibarica, Danais xanthorrhoea, Diospyros loureiriana ssp. rufescens, Erythrina sacleuxii, Newtonia paucijuga, Pentas lanceolata, Scorodophloeus fischeri, Stuhlmannia moavi, Tarenna pavettoides, Tessmannia burttii and Toussaintia orientalis growing in Tanzania were investigated using an imaging-based assay (antiplasmodial), well diffusion and microplate dilution methods (antimicrobial) and human embryonic kidney cells (HEK 293) and brine shrimp larvae assays (toxicity). The extracts exhibited activities of varying potencies and cytotoxicity with IC50 values ranging from 0.45 ± 0.09 to 75.70 ± 24.19 μg/mL against Plasmodium falciparum (3D7 strain), MIC ranging from 0.25 to 2.0 mg/mL (against Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Candida albicans and Cryptococcus neoformans), LC50 ranging from 0.75 to 1000 μg/mL against brine shrimp larvae (Artemia salina) and IC50 ranging from 4.02 ± 1.05 to more than 289 μg/mL against HEK 293 cells. The observed bioactivities of some of the investigated plant extracts validate their ethnomedicinal use and are indicative of the presence of bioactive ingredients for further phytochemical investigations.en_US
dc.identifier.citationBegum, S., Munissi, J. J., Buriyo, A. S., Makangara, J. J., Lucantoni, L., Avery, V. M., ... & Nyandoro, S. S. (2020). Antiplasmodial, antimicrobial and cytotoxic activities of extracts from selected medicinal plants growing in Tanzania. Journal of Biologically Active Products from Nature, 10(2), 165-176.en_US
dc.identifier.otherDOI: https://doi.org/10.1080/22311866.2020.1770125
dc.identifier.otherURL: https://www.tandfonline.com/doi/abs/10.1080/22311866.2020.1770125
dc.identifier.urihttp://hdl.handle.net/20.500.12661/3783
dc.language.isoenen_US
dc.publisherTaylor & Francisen_US
dc.subjectMedicinal plantsen_US
dc.subjectMalariaen_US
dc.subjectMicrobial infectionsen_US
dc.subjectAntiplasmodialen_US
dc.subjectAntimicrobialen_US
dc.subjectMalariaen_US
dc.subjectMicrobesen_US
dc.subjectAntimicrobial activitiesen_US
dc.subjectAntiplasmodial activitiesen_US
dc.subjectCytotoxic activitiesen_US
dc.subjectEthnomedicinal useen_US
dc.subjectMicrobial infectionsen_US
dc.subjectMalaria infectionsen_US
dc.titleAntiplasmodial, antimicrobial and cytotoxic activities of extracts from selected medicinal plants growing in Tanzaniaen_US
dc.typeArticleen_US
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