Development of bacterial resistant acrylamide-polyvinylpyrrolidone-metal oxide hydrogel nanocomposites

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dc.contributor.authorOwonubi, Shesan John
dc.contributor.authorAgwuncha, S.C.
dc.contributor.authorMalima, Nyemaga Masanje
dc.contributor.authorSadiku, E.R.
dc.contributor.authorRevaprasadu, Neerish
dc.date.accessioned2023-05-23T10:02:29Z
dc.date.available2023-05-23T10:02:29Z
dc.date.issued2021
dc.descriptionAbstract. Full text article available at https://doi.org/10.1016/j.matpr.2020.05.502en_US
dc.description.abstractFabrication of polymer-based nanocomposites for numerous biomedical applications represents a predominant form of therapeutics for combating microbial and bacterial infections. Herein, we firstly synthesized metal oxide nanoparticles (MONPs) by previously reported precipitation methods. Hydrogel nanocomposites were then prepared by free radical polymerization of a combination of the synthesized MONPs, polyvinylpyrrolidone (PVP) and acrylamide. The hydrogel nanocomposites were characterized by FTIR, XRD and investigated for potential antibacterial protection. FTIR spectra of the prepared hydrogel nanocomposites revealed significant characteristic peaks of the distinctive MONPs within the polymer matrix. XRD micrographs revealed slight shifting of peak positions in nanocomposites; the change in peak intensity, coupled with the observed slight shift in the diffraction peaks of both CuO and ZnO nanoparticles confirmed the successful incorporation of the MONPs into the polymer matrix. The presence of the MONPs, in combination with PVP, displayed a synergistic antibacterial activity, with increasing concentration of the MONPs. The treatment against S.pneumoniae, revealed a zone of inhibition phenomenon which showed zones of PVP-5 > PVP-8 > PVP-6 > PVP-9 > PVP-7. PVP-1, PVP-2, PVP-3, PVP-4 did not show any significant zone of inhibition on treatment due to the quantity of MONPs present. The findings show that the hydrogel nanocomposites are potential topical wound dressing materials for the management of bacterial infections.en_US
dc.identifier.citationOwonubi, S. J., Agwuncha, S. C., Malima, N. M., Sadiku, E. R., & Revaprasadu, N. (2021). Development of bacterial resistant acrylamide-polyvinylpyrrolidone-metal oxide hydrogel nanocomposites. Materials Today: Proceedings, (38),2, 982-987.en_US
dc.identifier.otherDOI:https://doi.org/10.1016/j.matpr.2020.05.502
dc.identifier.urihttp://hdl.handle.net/20.500.12661/3843
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.subjectBacterial infectionsen_US
dc.subjectPolyvinylpyrrolidoneen_US
dc.subjectPVPen_US
dc.subjectMetal oxide nanoparticlesen_US
dc.subjectHydrogel nanocompositesen_US
dc.subjectMicrobial infectionsen_US
dc.subjectNanoparticlesen_US
dc.subjectBiomedical applicationen_US
dc.subjectBacterial resistant acrylamideen_US
dc.subjectPolyvinylpyrrolidone-metalen_US
dc.subjectOxide hydrogelen_US
dc.titleDevelopment of bacterial resistant acrylamide-polyvinylpyrrolidone-metal oxide hydrogel nanocompositesen_US
dc.typeArticleen_US
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