ATP-induced nuclear and cytosolic ca2+ signal in various stages of interphase hela/fucci2 cell
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Date
2015
Journal Title
Journal ISSN
Volume Title
Publisher
Mohammad Nassar for Researches (MNFR)
Abstract
Cell cycle progression involves the coordination of growth, DNA replication and division in proliferating cells. These intracellular activities are linked with calcium signaling in which calcium ion (Ca2+) act as a second messenger or as an agent for phosphorylation processes. Previous studies have examined the Ca2+ in the dividing cells; however, none of these gave the detailed explanation on Ca2+ dynamics in an interphase cell. This study addresses here the issue of whether the nuclear and cytosolic Ca2+ concentrations ([Ca2+]n and [Ca2+]c) changes are related or not in the dividing interphase cells. Current approach used interphase HeLa/Fucci2 cells to investigate the intracellular Ca2+ dynamics between the nucleoplasm and cytoplasm following stimulation with extracellular adenosine triphosphate (extracellular purinergic-2 receptor agonists). The results revealed that [Ca2+]n and [Ca2+]c signals differed both between and within interphase stages.
Description
Abstract. Full text article is available at https://core.ac.uk/download/pdf/249334585.pdf
Keywords
ATP-induced nuclear, cytosolic ca2+ signal, DNA replication, Cell cycle progression, Interphase hela/fucci2 cell, Intracellular Ca2+ dynamics, Extracellular adenosine triphosphate
Citation
Mchonde, G. J., Satoh, Y. I., & Saino, T. (2015). ATP-Induced Nuclear and Cytosolic Ca 2 Signal in Various Stages of Interphase HeLa/Fucci2 Cell. Int. J. Sci.: Basic and Applied Res, 21, 274-286.