ATP-induced nuclear and cytosolic ca2+ signal in various stages of interphase hela/fucci2 cell

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dc.contributor.authorMchonde, Gabriel J.
dc.contributor.authorSatoh, Yoh-ichi
dc.contributor.authorSaino, Tomoyuki
dc.date.accessioned2023-05-22T12:43:33Z
dc.date.available2023-05-22T12:43:33Z
dc.date.issued2015
dc.descriptionAbstract. Full text article is available at https://core.ac.uk/download/pdf/249334585.pdfen_US
dc.description.abstractCell cycle progression involves the coordination of growth, DNA replication and division in proliferating cells. These intracellular activities are linked with calcium signaling in which calcium ion (Ca2+) act as a second messenger or as an agent for phosphorylation processes. Previous studies have examined the Ca2+ in the dividing cells; however, none of these gave the detailed explanation on Ca2+ dynamics in an interphase cell. This study addresses here the issue of whether the nuclear and cytosolic Ca2+ concentrations ([Ca2+]n and [Ca2+]c) changes are related or not in the dividing interphase cells. Current approach used interphase HeLa/Fucci2 cells to investigate the intracellular Ca2+ dynamics between the nucleoplasm and cytoplasm following stimulation with extracellular adenosine triphosphate (extracellular purinergic-2 receptor agonists). The results revealed that [Ca2+]n and [Ca2+]c signals differed both between and within interphase stages.en_US
dc.identifier.citationMchonde, G. J., Satoh, Y. I., & Saino, T. (2015). ATP-Induced Nuclear and Cytosolic Ca 2 Signal in Various Stages of Interphase HeLa/Fucci2 Cell. Int. J. Sci.: Basic and Applied Res, 21, 274-286.en_US
dc.identifier.otherURL: https://core.ac.uk/download/pdf/249334585.pdf
dc.identifier.urihttp://hdl.handle.net/20.500.12661/3779
dc.language.isoenen_US
dc.publisherMohammad Nassar for Researches (MNFR)en_US
dc.subjectATP-induced nuclearen_US
dc.subjectcytosolic ca2+ signalen_US
dc.subjectDNA replicationen_US
dc.subjectCell cycle progressionen_US
dc.subjectInterphase hela/fucci2 cellen_US
dc.subjectIntracellular Ca2+ dynamicsen_US
dc.subjectExtracellular adenosine triphosphateen_US
dc.titleATP-induced nuclear and cytosolic ca2+ signal in various stages of interphase hela/fucci2 cellen_US
dc.typeArticleen_US
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