Corruption in Tanzania is a major challenge. This article addresses the problem of corruption in four steps. Firstly, it describes the nature of corruption. Secondly, it analyses efforts so far to prevent corruption in Tanzania. Thirdly, it considers the Prevention and Combating of Corruption Bureau and the anti-corruption legislation of 2007 with a view to assessing whether they are sufficiently comprehensive to curb corruption in Tanzania. Fourthly, it looks at the effects of corruption in Tanzania. It concludes that the Prevention and Combating of Corruption Bureau does not have genuine independence and that the government which is needed to defeat corruption is the core of the problem.